Ageing International Colloquium 3rd Edition (October 14th 2024)
9-9:05 : Dr. Eric Bapteste (CNRS, MNHN, France) Welcome words
The current theoretical framework and some of its limits
9:05-9:30 : Pr. Suresh Rattan (Department of Molecular Biology and Genetics, Aarhus University, DENMARK) « Deepest open issues in the theories of ageing and its evolution»
Microbiome and Ageing
9:55-10:20 : Pr. Paul O’Toole (School of Microbiology & APC Microbiome Institute Room 447 Food Science Building, University College Cork, T12 Y337 Cork, Ireland.) « Contribution of the gut microbiome to human ageing at different ages »
10:20-10:45 : Pr. Dario Valenzano (Leibniz Institute on Ageing, Beutenbergstraße 1107745 Jena, Germany) « Evolution of the microbiome during host ageing and rejuvenation»
10:45-11:10 : Dr. François Trottein (Pasteur Lille, France) « Viral infections and mammalian aging »
Alternative models to study ageing
11:15-11:40 : Pr. Ulrich Karl Steiner (Institute of Biology, FU-Berlin, Germany) « Latest discoveries about bacterial ageing. »
11:40-12:05 : Dr. Mart Krupovic (Pasteur Institute, Paris, France) « First evidence of ageing in Archaea. »
12:05-12:30 : Dr. Jean-François Le Galliard (CNRS – UMS 3194, CEREEP-Ecotron IleDeFrance, Département de biologie, Ecole Normale Supérieure – PSL Research University, St-Pierre-lès-Nemours, France) “Ecology and ageing: lizard senescence as a case study”
Organisational complexity and ageing
14:15-14:40 : Mr. Thomas Duffield (Institute of Inflammation and Ageing ; University of Birmingham ; Queen Elizabeth Hospital ; Mindelsohn Way Birmingham, B15 2WB United Kingdom) « Epigenetics failure and ageing »
14:40-15:05 : Pr. Claudio Franceschi (U. Bologna, Italy) « Heterogeneity in individual ageing«
15:05-15:30 : Dr. Eric Chenin (IRD / UMMISCO, MNHN / GBIF France) “Three stages of system aging: malleability, elasticity and rigidity”
Evolution of ageing and ageing related diseases
15:35-16:00 : Dr. Samuel Pavard (MNHN, Paris, France) « Joint evolution of cancer and ageing related diseases in mammals »
16:00-16:25 : Mr. Hugo Bonnefous (SU, ISYEB, Paris, France) « Evolutionary history of Ageing-Related Disease genes ».
Conclusion
16:25-16:50 : Dr. Maël Lemoine (Université de Bordeaux, France) « What are the deepest philosophical issues about ageing and its evolution?»
Because some of the results that are presented in this talk are not published, this speaker didn’t wish to have his presentation available online but the PDF can be found here.
16:50-17:15 : Dr. Jessica Lombard (ETHICS – EA 7446, Université Catholique de Lille) « Transhumanist movements and Evolutionary theories of aging: Uses and Misuses »
Ageing International Colloquium 2nd Edition (October 19th 2023)
9:-9:05: Dr. Eric Bapteste (UMR ISYEB, CNRS, Paris) « A few welcome words »
The current theoretical framework and some of its limits
9:06-9:26: Pr. Annette Baudisch (University of Southern Denmark, DK) « How to bridge the gap between determined modes of demographical ageing – such as slow and negligible senescence among testudines- and biological ageing affecting organisms?»
9:27-9:47: Dr. Jean-François Lemaître (UMR CNRS 5558, Laboratoire Biométrie et Biologie Évolutive, Université Claude Bernard, Lyon, France) « Open issues associated with sex differences in ageing »
Ageing through the prism of interactions
9:48-10:08: Pr. Dan Franks (Departments of Biology and Computer Science, The University of York, UK) « How social organization affects ageing : the case of post-reproductive female killer whales and beyond. »
10:09-10:29: Dr. Samuel Pavard (MNHN, Paris, France) « What are the connections between the evolution of human ageing and human sociality ? »
10:35-10h55: Pr. Susanne Foitzik (Johannes Gutenberg University Mainz, Germany) « Parasite-induced lifespan prolongation and its molecular regulation in insects »
10h56-11:16:Pr. Laurent Keller (Social Evolution Unit, Chesières, Switzerland) « Challenges to understand ageing in the light of social structures and kin selection»
Alternative models to study ageing
11h17-11h37: Pr. Wolfgang Wagner (Uniklinik RWTH Aachen, Germany) « Can epigenetics govern ageing and how? »
11h38-11h58: Pr. David Gems (Institute of Healthy Ageing, University College London, UK) « Connections between developmental programs and ageing, the notion of quasi-programs and how questioning hallmarks of ageing may help us improve our understanding of ageing »
14h00-14h20: Pr. Joao Pedro de Magalhaes (virtual attendance) (University of Birmingham, UK) « Ageing as a software design flaw and its evolutionary aspects»
14h21-14 :41 : Dr. Michael Rera (Centre de Recherche Interdisciplinaire, INSERM UMR U1284, 75004 Paris, France) « Some thoughts on the
debates about the programmed vs non programmed nature of ageing«
Organisational complexity and ageing
14h42-15h02: Dr. Yifan Yang (Weizmann Institute of Sciences, Israel) « Latest discoveries about bacterial ageing. »
15h03-15h23: Dr. Chiara Sinigaglia (Observatoire Océanologique de Banyuls, Sorbonne Université, France) « Ageing in Cnidarians. »
15h24-15h44: Dr. Eric Bapteste (UMR ISYEB, CNRS, Paris) « Natural History of Ageing: how old is ageing? »
Microbiome and host ageing
15h50-16h10: Dr. Claudio Franceschi (University of Bologna, Italy) «The evolutionary origin of Inflammaging »
16h11-16h31: Pr. William Ludington (Carnegie Institution for Science, Johns Hopkins University, USA) « Open issues about microbiomes and ageing»
Conclusion
16h32-16h52: Dr. Clémence Guillermain (Université de Nantes, France) « What are the (specific) philosophical issues associated with ageing and with ageing studies? »
Ageing International Colloquium 1st Edition (May 10th 2022)
This colloquium was held partly online and partly on site on May 10th 2022 and was funded by Museum National d’Histoire Naturelle (MNHN, Paris).
“Expanding evolutionary theories of ageing to take into account symbioses and interactions throughout the Web of Life”.
This colloquium will seek to explore traditional limits to the main evolutionary theories of ageing and to propose novel findings to improve our understanding of how, why and when organisms age in the Web of Life. It will question the explanatory scope and the phylogenetic scope of at least three leading, stimulating evolutionary theories of ageing, namely the Mutation Accumulation theory, the Antagonistic pleiotropy theory and the Disposable Soma theory. Indeed, these theories share a common blindspot. The first two have been developed under the traditional framework of population genetics, and therefore are logically centered on the ageing of individuals within a population or within a species. The third one is usually applied to explain ageing within a species. Consequently, these theories do not explicitly model the countless interspecific and ecological interactions, such as symbioses and host-microbiomes associations, however well-known to affect many organismal traits as well as organismal evolution. Moreover, these theories have been mostly developed with animal models in mind, mainly those with a neat germen/soma distinction, such as mice and humans, and for this reason all these theories may benefit from novel conceptual developments to further justify and possibly expand their application scope towards other taxa, such as unicellular organisms (protists, bacteria and archaea), which have long been considered, by default and probably erroneously, as non-senescent, and such as extremely long lived taxa, which owing to their unusual biology may still have some lessons to contribute to these theories.
Scientific program :
8:45-8:50AM: A quick introduction and welcome words (E. Bapteste)
Current theoretical framework and some of its limits
8:51-9:21: Pr. Annette Baudisch (University of Southern Denmark, DK) « The diversity of ageing patterns in the phylogeny of Life.»
9:22-9:52: Pr. Joao Pedro de Magalhaes (University of Liverpool, UK) « Some thoughts on the limits to our understanding of the genetic, cellular and molecular mechanisms of ageing throughout the Tree of life. »
9:53-10:23: Pr. Emma Teeling (University College Dublin, Ireland) « Lessons from bats and possibly other long-lived species longevity analyses, and the importance to study ageing in natural populations. »
Ageing through the prism of interactions
10:23-10:53: Pr. Laurent Keller (University of Lausanne, Switzerland) « Diversity of ageing patterns in relation with the social interactions within ageing species »
10:54-11:24: Dr. Ophélie Ronce (CNRS, France): « Evolution of ageing in a changing environment »
11:25-11h55: Dr. Jérôme Teulière (ISYEB, Paris, France) « Phylosystemics of ageing : inferring ancestral longevity networks. »
11h56-12:26: Dr. Eric Bapteste (ISYEB, Paris, France) « Interspecific interactions that affect ageing: introducing age-distorters that manipulate host ageing to their own evolutionary benefits. »
LUNCH BREAK
Unicellularity and ageing
14:00-14:30: Dr. Ariel B. Lindner (INSERM, Université Paris Cité, France) « Ageing patterns in bacteria »
14:31-15:01: Dr. Virginija Cvirkaite-Krupovic (Pasteur, France) « Asymmetric cell division in Archaea infected by viruses and possible connection to ageing »
15:02-15:32: Dr. Francesco Catania (International Visiting Scholar at Fukushima University, Institute of Environmental Radioactivity, Japan) « Ageing in protists and/or what a protistologist perspective may bring to ageing studies »
Microbiome and host ageing
15:33-16:03: Pr. William Ludington (Carnegie Institution for Science, Johns Hopkins University, USA) « Impact of microbiomes on host ageing across the Tree of Life»
16:04-16:34 : Pr. Claudio Franceschi (University of Bologna, Italy) « Connections between microbiomes, viruses and host ageing »
16:35-17:05: Dr. François Leulier (Institut de Génomique Fonctionnelle de Lyon, France) « Microbiome, ageing and nutrition »
Conclusion:
17:06-17:36: Dr. Philippe Huneman (CNRS, France) « Main philosophical issues associated with ageing and with ageing studies »